Nov 05, 2006 · The MUC1 gene encodes a mucin glycoprotein(s) which is basally expressed in most epithelial cells. In breast adenocarcinoma and a variety of epithelial tumors its transcription is dramatically upregulated. Of particular relevance to breast cancer, steroid hormones also stimulate the expression of the MUC1 gene. The MUC1 gene directs expression of several protein isoforms, which Cited by: 71. Breast cancer is the most common cancer among women in the world. One of the approaches for diagnosis of breast cancer is detection of its tumor-associated markers. Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein expressed by normal epithelial cells and overexpressed by carcinomas of epithelial origin.
May 24, 2019 · The MUC1 protein is recognized as the second most targetable tumor antigen. MUC1 is expressed in over 90% of breast cancer, making MUC1 the most relevant and important antigen for breast cancer targeting. Furthermore, MUC1 is expressed on 95% of TNBC.Author: R. S. Zhou, Mahboubeh Yazdanifar, Lopamudra Das Roy, Lynsey May Whilding, Artemis Gavrill, John Mich. Dec 23, 2018 · MUC1-C and Rab31 function in an autoinductive loop that contributes to overexpression of MUC1-C in breast cancer cells. the crosstalk between MUC1 and c-Met in HCC could provide an advantage for invasion to HCC cells through the beta-catenin/c-Myc pathway.
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Finally, antibodies to MUC1 are also used in breast cancer management to detect MUC1 in serum in an attempt to detect relapse before clinical symptoms appear. Antibodies to MUC1 initiated interest in the MUC1 mucin and also led to the cloning of the gene coding for the core protein.Cited by: 562. Apr 05, 2019 · In breast and bladder micropapillary carcinoma, MUC1 stains stroma-facing surface of cell clusters (basal), which accentuates outlines of micropapillary units to form a distinct band on this surface Distinguish systemic anaplastic large cell lymphoma (MUC1+) from cutaneous anaplastic large cell lymphoma (usually MUC1-, Am J Surg Pathol 2008;32.
Jul 16, 2019 · Minerva Biotechnologies has developed a CAR T (huMNC2-CAR44) that targets the extra cellular domain of the cleaved form of MUC1 (called MUC1*), which is the form of MUC1 that functions as a growth factor receptor and is present on large percentage of solid tumors, including breast tumors.